Biology (BIOL) Courses
BIOL 5001 [0.5 credit] (BIO 5101)
Topics in Biotechnology
A course concerned with the use of biological substances and activities of cells, genes, and enzymes in manufacturing, agricultural, and service industries. A different topic will be selected each year.
Topics in Biotechnology
A course concerned with the use of biological substances and activities of cells, genes, and enzymes in manufacturing, agricultural, and service industries. A different topic will be selected each year.
Prerequisite(s): a course in cell physiology or biochemistry, or permission of the instructor and permission of the director or associate director of OCIB.
BIOL 5003 [0.5 credit] (BIO 5103)
Advanced Biochemistry
Advanced topics in biochemistry: the chemical structure and function of biological macromolecules, biochemical thermodynamics, metabolism, photosynthesis, lipids and membranes.
Advanced Biochemistry
Advanced topics in biochemistry: the chemical structure and function of biological macromolecules, biochemical thermodynamics, metabolism, photosynthesis, lipids and membranes.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5004 [0.5 credit] (BIO 5104)
Advances in Applied Biochemistry
Contemporary methods in recombinant DNA technology and protein characterization, including advanced techniques in proteomics.
Advances in Applied Biochemistry
Contemporary methods in recombinant DNA technology and protein characterization, including advanced techniques in proteomics.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5105 [0.5 credit] (BIO 5302)
Methods in Molecular Genetics
Theory and associated applications of emerging methods in molecular genetics, including information gathered from large-scale genome-wide analysis and protein-protein interaction data, and how this information can advance understanding of cell biology.
Methods in Molecular Genetics
Theory and associated applications of emerging methods in molecular genetics, including information gathered from large-scale genome-wide analysis and protein-protein interaction data, and how this information can advance understanding of cell biology.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5106 [0.5 credit] (BIO 5308)
Laboratory Techniques in Molecular Genetics
Laboratory course designed to give students practical experience in recent important techniques in molecular genetics.
Laboratory Techniques in Molecular Genetics
Laboratory course designed to give students practical experience in recent important techniques in molecular genetics.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5111 [0.5 credit] (BIO 5111)
Biophysical Techniques
Theory and application of current biochemical/biophysical instrumentation and techniques including X-ray crystallography, nuclear magnetic resonance spectrometry, infrared, circular dichroism and fluorescence spectroscopy, and isothermal titration and differential scanning calorimetry.
Biophysical Techniques
Theory and application of current biochemical/biophysical instrumentation and techniques including X-ray crystallography, nuclear magnetic resonance spectrometry, infrared, circular dichroism and fluorescence spectroscopy, and isothermal titration and differential scanning calorimetry.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5121 [0.5 credit] (BIO 5121)
Advances in Protein Engineering
An advanced lecture, discussion and seminar course covering the theory, development and current techniques of protein and enzyme engineering. Topics to be discussed may also include applications in biotechnology, nanotechnology and new frontiers in basic and applied research.
Advances in Protein Engineering
An advanced lecture, discussion and seminar course covering the theory, development and current techniques of protein and enzyme engineering. Topics to be discussed may also include applications in biotechnology, nanotechnology and new frontiers in basic and applied research.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5201 [0.5 credit] (BIO 8301)
Evolutionary Bioinformatics
Basic concepts in molecular evolution and hands-on experience with the computer analysis of DNA sequences. Topics may include molecular sequence databases, multiple alignments and phylogenetic trees.
Evolutionary Bioinformatics
Basic concepts in molecular evolution and hands-on experience with the computer analysis of DNA sequences. Topics may include molecular sequence databases, multiple alignments and phylogenetic trees.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5202 [0.5 credit] (BIO 8302)
Topics in Evolutionary Genetics
A lecture/seminar course on the genetic mechanisms and forces responsible for variation and evolutionary change in natural populations.Topics to include protein and genome evolution, molecular phylogenies, DNA sequences in population biology, and the evolution of multigene families.
Topics in Evolutionary Genetics
A lecture/seminar course on the genetic mechanisms and forces responsible for variation and evolutionary change in natural populations.Topics to include protein and genome evolution, molecular phylogenies, DNA sequences in population biology, and the evolution of multigene families.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5203 [0.5 credit] (BIO 8303)
Advanced Microscopy
Development of the practical skills of microscopy through original research and supporting theory lectures.
Advanced Microscopy
Development of the practical skills of microscopy through original research and supporting theory lectures.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5304 [1.0 credit]
Fundamentals in Neuroscience
A comprehensive neuroscience course from cellular levels to neural systems and behaviour. Topics covered include aspects of neuroanatomy, neurophysiology, neuropharmacology and behavioural and cognitive neuroscience.
Fundamentals in Neuroscience
A comprehensive neuroscience course from cellular levels to neural systems and behaviour. Topics covered include aspects of neuroanatomy, neurophysiology, neuropharmacology and behavioural and cognitive neuroscience.
BIOL 5307 [0.5 credit] (BIO 8122)
Advanced Insect Biology
Overview of the biological processes that allow insects to function in their environments and to overcome the constraints and limitations that the environment places on them.
Advanced Insect Biology
Overview of the biological processes that allow insects to function in their environments and to overcome the constraints and limitations that the environment places on them.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5402 [0.5 credit] (BIO 8162)
Advanced Endocrinology
Major topics in comparative endocrinology: understanding the structure, function and evolution of vertebrate endocrine systems, including endocrine disruption.
Advanced Endocrinology
Major topics in comparative endocrinology: understanding the structure, function and evolution of vertebrate endocrine systems, including endocrine disruption.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5407 [0.5 credit] (BIO 5305)
Biostatistics I
Application of statistical analyses to biological data. Topics include ANOVA, regression, GLMs, and may include loglinear models, logistic regression, general additive models, mixed models, bootstrap and permutation tests.
Biostatistics I
Application of statistical analyses to biological data. Topics include ANOVA, regression, GLMs, and may include loglinear models, logistic regression, general additive models, mixed models, bootstrap and permutation tests.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5409 [0.5 credit] (BIO 5306)
Modelling for Biologists
Use and limitations of mathematical and simulation modelling approaches for the study of biological phenomena.
Modelling for Biologists
Use and limitations of mathematical and simulation modelling approaches for the study of biological phenomena.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5501 [0.5 credit] (BIO 8900)
Directed Studies in Biology
One-to-one instruction in selected aspects of specialized biological subjects not covered by other graduate courses. Students may not take this course from their thesis supervisor(s), and are limited to one directed studies course per program.
Directed Studies in Biology
One-to-one instruction in selected aspects of specialized biological subjects not covered by other graduate courses. Students may not take this course from their thesis supervisor(s), and are limited to one directed studies course per program.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5502 [0.5 credit] (BIO 8120)
Selected Topics in Biology
Lecture and seminar courses in selected aspects of specialized biological subjects not covered by other graduate courses.
Selected Topics in Biology
Lecture and seminar courses in selected aspects of specialized biological subjects not covered by other graduate courses.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5503 [0.5 credit] (BIO 5901)
Biological Science in Practice
Introduction to cross-cutting skills and issues in common to all biological disciplines. Key perspectives on philosophy of science, practical approaches to scientific publication and peer-review, data analysis and presentation, scientific inference, and technical writing will be provided through discipline-specific examples and associated practical work.
Biological Science in Practice
Introduction to cross-cutting skills and issues in common to all biological disciplines. Key perspectives on philosophy of science, practical approaches to scientific publication and peer-review, data analysis and presentation, scientific inference, and technical writing will be provided through discipline-specific examples and associated practical work.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5506 [0.5 credit] (BIO 5213)
Principles and Methods of Biological Systematics
Biological systematics with reference to morphological and molecular character evolution and phylogeny reconstruction.
Principles and Methods of Biological Systematics
Biological systematics with reference to morphological and molecular character evolution and phylogeny reconstruction.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5508 [0.5 credit] (BIO 8306)
Advanced Topics in Ecology
Recent developments in population, community and/or ecosystem ecology.
Advanced Topics in Ecology
Recent developments in population, community and/or ecosystem ecology.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5510 [0.5 credit] (BIO 5310)
Advanced Evolutionary Biology
Advances in micro- and macroevolution including the mechanisms both driving and constraining evolutionary change, phylogenetic relationships, patterns of evolutionary change at the molecular or phenotypic level, and evolutionary theory and techniques as applied to these areas.
Advanced Evolutionary Biology
Advances in micro- and macroevolution including the mechanisms both driving and constraining evolutionary change, phylogenetic relationships, patterns of evolutionary change at the molecular or phenotypic level, and evolutionary theory and techniques as applied to these areas.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5511 [0.5 credit] (BIO 5311)
Advanced Evolutionary Ecology
The ecological causes and consequences of evolutionary change, focussing on how the ecological interactions among organisms and their biotic and abiotic environments shape the evolution of phenotypic and species diversity.
Advanced Evolutionary Ecology
The ecological causes and consequences of evolutionary change, focussing on how the ecological interactions among organisms and their biotic and abiotic environments shape the evolution of phenotypic and species diversity.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5512 [0.5 credit] (BIO 8105)
Advances in Applied Ecology
The application of ecological and evolutionary principles in addressing resource management challenges and environmental problems.
Advances in Applied Ecology
The application of ecological and evolutionary principles in addressing resource management challenges and environmental problems.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5514 [0.5 credit] (BIO 5314)
Advances in Aquatic Sciences
Advanced theoretical and applied aquatic sciences including current topics in limnology and oceanography (e.g. impacts of climate change, invasive species, atmospheric pollution) with implications for lake, river, coastal and wetland management.
Advances in Aquatic Sciences
Advanced theoretical and applied aquatic sciences including current topics in limnology and oceanography (e.g. impacts of climate change, invasive species, atmospheric pollution) with implications for lake, river, coastal and wetland management.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5515 [0.5 credit] (BNF 5106)
Bioinformatics
Major concepts and methods of bioinformatics. Topics may include genetics, statistics and probability theory, alignments, phylogenetics, genomics, data mining, protein structure, cell simulation and computing.
Bioinformatics
Major concepts and methods of bioinformatics. Topics may include genetics, statistics and probability theory, alignments, phylogenetics, genomics, data mining, protein structure, cell simulation and computing.
BIOL 5516 [0.5 credit] (BNF 5107)
Applied Bioinformatics
Computational knowledge discovery in and the dynamic nature of cellular networks. Includes, but is not limited to, knowledge representation, large scale data integration, data mining and computational systems biology.
Applied Bioinformatics
Computational knowledge discovery in and the dynamic nature of cellular networks. Includes, but is not limited to, knowledge representation, large scale data integration, data mining and computational systems biology.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5517 [0.5 credit] (BNF 6100)
Bioinformatics Seminar
Current topics in bioinformatics. Students must successfully complete a presentation and written report.
Bioinformatics Seminar
Current topics in bioinformatics. Students must successfully complete a presentation and written report.
BIOL 5518 [0.5 credit] (BNF 5318)
Biostatistics II
Application of multivariate methods to biological data, including methods such as discriminant functions analysis, cluster analysis, MANOVA, principle components analysis.
Biostatistics II
Application of multivariate methods to biological data, including methods such as discriminant functions analysis, cluster analysis, MANOVA, principle components analysis.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5520 [0.5 credit] (BIO 5320)
Advances in Conservation Biology
Interdisciplinary exploration of the science of scarcity and diversity in a human dominated world.
Advances in Conservation Biology
Interdisciplinary exploration of the science of scarcity and diversity in a human dominated world.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5521 [0.5 credit] (BIO 5321)
Evolutionary Genetics
Genetic mechanisms and processes responsible for variation and evolutionary change in natural populations. Topics may include population and quantitative genetics as applied to protein and genome evolution, molecular phylogenies, DNA sequences in population biology, and the evolution of multigene families.
Evolutionary Genetics
Genetic mechanisms and processes responsible for variation and evolutionary change in natural populations. Topics may include population and quantitative genetics as applied to protein and genome evolution, molecular phylogenies, DNA sequences in population biology, and the evolution of multigene families.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5605 [0.5 credit] (BIO 5102)
Advanced Field Ecology
Field experience in a new environment (e.g., local, national, international) to learn about ecological processes (note - extra fees associated with course).
Advanced Field Ecology
Field experience in a new environment (e.g., local, national, international) to learn about ecological processes (note - extra fees associated with course).
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5709 [0.5 credit] (BIO 8113)
Chemical Toxicology
An introduction to modeling chemical hazards and exposures at the cellular level. The properties of toxic substances are compared to the responses of enzymatic systems. These interactions are defined as Quantitative Structure-Activity Relationships and used to interpret hazardous materials under regulations such as WHMIS.
Chemical Toxicology
An introduction to modeling chemical hazards and exposures at the cellular level. The properties of toxic substances are compared to the responses of enzymatic systems. These interactions are defined as Quantitative Structure-Activity Relationships and used to interpret hazardous materials under regulations such as WHMIS.
Also listed as CHEM 5709/CHM 8157.
Prerequisite(s): BIOL 6402/CHEM 5708 (BIO 9101/CHM 8156), and permission of the director or associate director of OCIB.
Prerequisite(s): BIOL 6402/CHEM 5708 (BIO 9101/CHM 8156), and permission of the director or associate director of OCIB.
BIOL 5801 [0.5 credit] (BIO 5105)
Advanced Neuroethology
A comparative and evolutionary approach to studying neural mechanisms underlying animal behaviour, including genetic, neural and hormonal influences on behaviour.
Advanced Neuroethology
A comparative and evolutionary approach to studying neural mechanisms underlying animal behaviour, including genetic, neural and hormonal influences on behaviour.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 5802 [0.5 credit] (BIO 8365)
Advanced Behavioural Ecology
Recent advances in behavioural ecology including topics such as the evolution of tactics and strategies of group living, foraging, anti-predation, resource use and defence, cooperation, reproduction, and parental care.
Advanced Behavioural Ecology
Recent advances in behavioural ecology including topics such as the evolution of tactics and strategies of group living, foraging, anti-predation, resource use and defence, cooperation, reproduction, and parental care.
Prerequisite(s): Either BIOL 3802 or BIOL 3804 or equivalent AND permission of the director or associate director of OCIB.
BIOL 5909 [4.0 credits] (BIO 7999)
M.Sc. Thesis
M.Sc. Thesis
BIOL 6001 [0.5 credit] (BIO 8109)
Advanced Molecular Biology
In-depth coverage of the structure, function, and synthesis of DNA, RNA, and proteins.
Advanced Molecular Biology
In-depth coverage of the structure, function, and synthesis of DNA, RNA, and proteins.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 6002 [0.5 credit] (BIO 8116)
Advances in Plant Molecular Biology
Use of molecular genetics in general plant biology and the contribution of plant genomics to our understanding of plant metabolism, plant development, and plant interactions with the environment at the molecular, genome, and cellular levels.
Advances in Plant Molecular Biology
Use of molecular genetics in general plant biology and the contribution of plant genomics to our understanding of plant metabolism, plant development, and plant interactions with the environment at the molecular, genome, and cellular levels.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 6201 [0.5 credit] (BIO 8117)
Advanced Cell Biology
Recent advances in cell biology, including such topics as membranes, signalling, the cytoskeleton and control of the cell cycle.
Advanced Cell Biology
Recent advances in cell biology, including such topics as membranes, signalling, the cytoskeleton and control of the cell cycle.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 6202 [0.5 credit] (BIO 8118)
Advanced Cell Biology II
Topics for discussion may include: the structure, composition and three-dimensional organization of the nucleus, mechanisms and regulation of genome replication, structure organization of transcription. Nuclear reorganization during gamete development, fertilization, viral infection and the mitotic cell cycle. Normally offered in alternate years.
Advanced Cell Biology II
Topics for discussion may include: the structure, composition and three-dimensional organization of the nucleus, mechanisms and regulation of genome replication, structure organization of transcription. Nuclear reorganization during gamete development, fertilization, viral infection and the mitotic cell cycle. Normally offered in alternate years.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 6203 [0.5 credit] (BIO 6103)
Special Topics in Neuroscience
In-depth study of current topics in neuroscience. Course content varies yearly and has recently included cognitive neuroscience, neuropharmacology, neurodegeneration, and behavioural medicine.
Special Topics in Neuroscience
In-depth study of current topics in neuroscience. Course content varies yearly and has recently included cognitive neuroscience, neuropharmacology, neurodegeneration, and behavioural medicine.
Also listed as NEUR 5800.
BIOL 6204 [0.5 credit] (BIO 6304)
Techniques in Neuroscience
Completion of a research project carried out under the supervision of a neuroscience faculty member, normally not the current supervisor. The student will learn a new neuroscience technique and apply it to a research objective. Students must obtain prior approval from the graduate committee.
Techniques in Neuroscience
Completion of a research project carried out under the supervision of a neuroscience faculty member, normally not the current supervisor. The student will learn a new neuroscience technique and apply it to a research objective. Students must obtain prior approval from the graduate committee.
BIOL 6300 [0.5 credit] (BIO 8320)
Advanced Plant Biology
Recent developments in plant biology. Topics may include plant anatomy, systematics, evolution, genetics, ecology, ethnobotany, cell biology, and/or biotechnology.
Advanced Plant Biology
Recent developments in plant biology. Topics may include plant anatomy, systematics, evolution, genetics, ecology, ethnobotany, cell biology, and/or biotechnology.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 6304 [0.5 credit] (BIO 8361)
Advanced Animal Physiology
Recent advances in animal physiology, emphasizing comparative, evolutionary and environmental approaches.
Advanced Animal Physiology
Recent advances in animal physiology, emphasizing comparative, evolutionary and environmental approaches.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 6305 [1.0 credit] (BIO 6305)
Advanced Seminar in Neuroscience
A comprehensive pro-seminar series, covering issues ranging from cellular and molecular processes through to neural systems and behaviours as well as psychopathology. Students will also be required to attend the neuroscience colloquia series as part of this course.
Advanced Seminar in Neuroscience
A comprehensive pro-seminar series, covering issues ranging from cellular and molecular processes through to neural systems and behaviours as well as psychopathology. Students will also be required to attend the neuroscience colloquia series as part of this course.
Also listed as NEUR 6100.
Precludes additional credit for PSYC 6200, PSYC 6202, PSYC 6203, BIOL 6303.
Prerequisite(s): BIOL 5304 or equivalent.
Precludes additional credit for PSYC 6200, PSYC 6202, PSYC 6203, BIOL 6303.
Prerequisite(s): BIOL 5304 or equivalent.
BIOL 6402 [0.5 credit] (BIO 9101)
Principles of Toxicology
The basic theorems of toxicology with examples of current research problems. The concepts of exposure, hazard and risk assessment will be defined and illustrated with experimental material from some of the more dynamic areas of modern research.
Principles of Toxicology
The basic theorems of toxicology with examples of current research problems. The concepts of exposure, hazard and risk assessment will be defined and illustrated with experimental material from some of the more dynamic areas of modern research.
Also listed as CHEM 5708/CHM 8156/TOX8156.
Prerequisite(s): permission of the director or associate director of OCIB.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 6403 [0.5 credit] (BIO 9104)
Ecotoxicology
Advances in ecotoxicology with emphasis on the biological effects of contaminants. The potential for biotic perturbance resulting from chronic and acute exposure of ecosystems to selected toxicants will be covered along with the methods pesticide, herbicide and pollutant residue analysis and the concept of bound residues.
Ecotoxicology
Advances in ecotoxicology with emphasis on the biological effects of contaminants. The potential for biotic perturbance resulting from chronic and acute exposure of ecosystems to selected toxicants will be covered along with the methods pesticide, herbicide and pollutant residue analysis and the concept of bound residues.
Also listed as CHEM 5705/CHM 9109/TOX9104.
Prerequisite(s): BIOL 6402/CHEM 5708 (BIO 9101/CHM 8156), permission of the director or associate director of OCIB.
Prerequisite(s): BIOL 6402/CHEM 5708 (BIO 9101/CHM 8156), permission of the director or associate director of OCIB.
BIOL 6404 [0.5 credit] (BIO 8938)
Plant: Animal Interactions
The biology of co-evolutionary relationships between plants and phytophagous animals.
Plant: Animal Interactions
The biology of co-evolutionary relationships between plants and phytophagous animals.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 6405 [0.5 credit] (BIO 9105)
Seminar in Toxicology
A seminar course highlighting current topics in toxicology. The student will present a seminar and submit a report on the seminar topic. Student, faculty and invited seminar speakers.
Seminar in Toxicology
A seminar course highlighting current topics in toxicology. The student will present a seminar and submit a report on the seminar topic. Student, faculty and invited seminar speakers.
Also listed as CHEM 5805/CHM 8167/TOX9105.
Prerequisite(s): permission of the director or associate director of OCIB.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 6406 [0.5 credit] (BIO 9106)
Genetic Toxicology
Topics in mutagenesis and DNA repair, including spontaneous and induced mutagenesis, genetic toxicology testing, the genetics and biochemistry of replication, DNA repair and recombination, and the role of mutagens in the development of genetic disease and cancer.
Genetic Toxicology
Topics in mutagenesis and DNA repair, including spontaneous and induced mutagenesis, genetic toxicology testing, the genetics and biochemistry of replication, DNA repair and recombination, and the role of mutagens in the development of genetic disease and cancer.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 6505 [0.5 credit] (BIO 8108)
Advanced Topics in Development
Recent advances in developmental biology. Topics may include embryonic induction, regulation of morphogenesis and differentiation, mechanisms of regional specification and pattern formation, and developmental genetics. Offered in alternate years.
Advanced Topics in Development
Recent advances in developmental biology. Topics may include embryonic induction, regulation of morphogenesis and differentiation, mechanisms of regional specification and pattern formation, and developmental genetics. Offered in alternate years.
Prerequisite(s): permission of the director or associate director of OCIB.
BIOL 6909 [15.0 credits] (BIO 9999)
Ph.D. Thesis
Ph.D. Thesis
Summer session: some of the courses listed in this Calendar are offered during the summer. Hours and scheduling for summer session courses will differ significantly from those reported in the fall/winter Calendar. To determine the scheduling and hours for summer session classes, consult the class schedule at central.carleton.ca
Not all courses listed are offered in a given year. For an up-to-date statement of course offerings for the current session and to determine the term of offering, consult the class schedule at central.carleton.ca